Myeloid Neoplasia A functional variant in the core promoter of the CD95 cell death receptor gene predicts prognosis in acute promyelocytic leukemia Running Title: CD95 SNP rs2234767 in APL
نویسندگان
چکیده
Newcastle Cancer Centre, Northern Institute for Cancer Research, Paul O’Gorman Building, Newcastle University, Newcastle-upon-Tyne. NE2 4HH. United Kingdom. Department of Biology, University of York, Heslington, York. YO10 5DD Department of Haematology, School of Medicine, Cardiff University, Cardiff, United Kingdom. CF14 4XN. Department of Medical and Molecular Genetics, King’s College London School of Medicine, London, United Kingdom. SE1 9RT. Department of Haematology, Royal Victoria Infirmary, Newcastle-upon-Tyne, UK. NE1 4LP.
منابع مشابه
A functional variant in the core promoter of the CD95 cell death receptor gene predicts prognosis in acute promyelocytic leukemia.
Up to 15% of acute promyelocytic leukemia (APL) patients fail to achieve or maintain remission. We investigated a common G > A polymorphism at position -1377 (rs2234767) in the core promoter of the CD95 cell death receptor gene in 708 subjects with acute myeloid leukemia, including 231 patients with APL. Compared with the GG genotype, carrier status for the -1377A variant was associated with a ...
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